Water → 2-Amino-4,5-bis(furan-2-yl)oxazole

HRID 644396노트

반응식

HRID 644396 반응식
[CH:1]1[CH:5]=[C:4]([CH:6]([OH:14])[C:7]([C:9]2[O:13][CH:12]=[CH:11][CH:10]=2)=O)[O:3][CH:2]=1.[N:15]#[C:16][NH2:17].[O-]CC.[Na+].O>C(O)C>[NH2:17][C:16]1[O:14][C:6]([C:4]2[O:3][CH:2]=[CH:1][CH:5]=2)=[C:7]([C:9]2[O:13][CH:12]=[CH:11][CH:10]=2)[N:15]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 9864CyanamideHCID 11100FuroinHCID 2723922Sodium ethoxide

생성물 1

HCID 126152352-Amino-4,5-bis(furan-2-yl)oxazole수율 31.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Furoin (0.50 g, 2.60 mmol) was dissolved in ethanol (15 mL). Cyanamide (218.8 mg, 5.20 mmol) and sodium ethoxide (530.8 mg, 7.80 mmol) were added, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=1:1→1:2) to give the title compound (175.0 mg, 31.1%) as a dark brown crystal.

후처리

  1. extractionextracted with ethyl acetate
  2. washAfter the organic layer was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customthe residue obtained by evaporation under reduced pressure
  5. customwas purified by chromatography on silica gel (hexane:ethyl acetate=1:1→1:2)

출처 및 근거

ORD 기록
ord-1655b32d44d14cf7acd24f510b2e761c
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700655B2

반응 노트

불러오는 중…