5-Bromo-2-acetylsalicylic acid → Acetoxy-5-bromo-N-{4-[(1,1-dimethyl)ethyl]thiazol-2-yl}benzamide

반응식

[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([OH:9])=O)(=[O:3])[CH3:2].[NH2:15][C:16]1[S:17][CH:18]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[N:20]=1>>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:6]=1[C:7]([NH:15][C:16]1[S:17][CH:18]=[C:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[N:20]=1)=[O:9])(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 739225-Bromo-2-acetylsalicylic acid

HCID 27342024-tert-Butyl-1,3-thiazol-2-amine

생성물 1

HCID 85823490Acetoxy-5-bromo-N-{4-[(1,1-dimethyl)ethyl]thiazol-2-yl}benzamide수율 59.4%

실험 절차

Using 2-acetoxy-5-bromobenzoic acid and 2-amino-4-[(1,1-dimethyl)ethyl]thiazole as the raw materials, the same operation as the Example 24 gave the title compound.

출처 및 근거

ORD 기록: ord-fba94b1d87a3461197072b40b133d2a4
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07700655B2

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