1-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one → HCID 68680777, 화합물
반응식
C[O:2][C:3](=O)[CH:4]=[CH:5][C:6]1[C:14]2[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[N:11][C:10]=2[CH:9]=[C:8]([C:21]([F:24])([F:23])[F:22])[CH:7]=1.CN1CC[N:30]([C:33](=O)[CH:34]=[CH:35]C2C3N(C4C=CC=CC=4)C=NC=3C=C(C(F)(F)F)C=2)CC1>>[C:15]1([N:13]2[C:14]3[C:6]([CH:5]=[CH:4][C:3]([NH:30][CH2:33][CH2:34][CH3:35])=[O:2])=[CH:7][C:8]([C:21]([F:22])([F:23])[F:24])=[CH:9][C:10]=3[N:11]=[CH:12]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1참가 물질
3
실험 절차
This was prepared from 3-(3-phenyl-6-trifluoromethyl-3H-benzoimidazol-4-yl)acrylic acid methyl ester in a similar manner to 1-(4-methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one. The oily residue was purified by preparative LCMS to afford, after removal of the solvent, the title compound as a white solid (16 mg, 6%), m/z 374.0 (M+H)+.
후처리
- customThe oily residue was purified by preparative LCMS