Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 64459생성일: 2026년 10월 23일
Cyclopentanemethanol → N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
https://huagongshe.com/ko/reaction/64459
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclopentanemethanol | HCID 77195 | — |
| 반응물 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 반응물 | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713409 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713474 | — |
반응 단계
A mixture of 120 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide, 60 μl of cyclopentylmethanol, 156 μl of (tributylphosphoranylidene)acetonitrile, and 2.4 ml of toluene was stirred at 110° C. for 16 hours, followed by purification using silica gel chromatography, to obtain 100 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09447090B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-5ab65197b73f4c0aac187c473560d72d |
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| 출처 메모 | uspto-grants-2016_09 |
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