Phenylacetylene → 1-Benzyl-4-phenyl-1,2,3-triazole

HRID 64497

반응식

HRID 64497 반응식
[C:1]1([C:7]#[CH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:9]([N:16]=[N+:17]=[N-:18])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>ClCCl>[CH2:9]([N:16]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:18]=[N:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 10821PhenylacetyleneHCID 12152Benzyl azide

생성물 1

HCID 113108941-Benzyl-4-phenyl-1,2,3-triazole수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Phenylacetylene (103 mg, 1.0 mmol, 1.0 eq.) and benzyl azide (133 mg, 1.0 mmol, 1.0 eq.) were dissolved in an air-tight lockable vial with a septum in 10 mL dry dichloromethane. The Cu complex (catalytic or stoichiometric amounts) shown below was added, the vial sealed and the reaction stirred at room temperature for 2 days. For the removal of the catalyst complex the reaction mixture was put in 50 mL methanol and stirred for 20 min. The complex was removed by filtering and the filtrate was concentrated. Removal of the solvent and drying of the product in high vacuum resulted in the compound 1-benzyl-4-phenyl-1H-1,2,3-triazole as light yellow solid with 95% yield (245 mg, 0.95 mmol). The identity of the product was proven by NMR-spectroscopy, infrared spectroscopy and high-resolution mass spectroscopy.

후처리

  1. additionbelow was added
  2. customthe vial sealed
  3. customFor the removal of the catalyst complex the reaction mixture
  4. stirringstirred for 20 min
  5. customThe complex was removed
  6. filtrationby filtering
  7. concentrationthe filtrate was concentrated
  8. customRemoval of the solvent
  9. customdrying of the product in high vacuum

출처 및 근거

ORD 기록
ord-501c5620fdde4b33b511a2d682e2a9d3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447245B2

연결된 노트

불러오는 중…