Dimethylformamide → HCID 59263843, 화합물

HRID 644976노트

반응식

HRID 644976 반응식
[CH2:1]([O:8][C:9]([N:11]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[CH2:12][CH2:13][C:14](O)=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:27]C1C(Cl)=CC=CC=1CCN.C(Cl)(=O)C(Cl)=O.CN(C=O)C>ClCCl>[Cl:27][C:14](=[O:15])[CH2:13][CH2:12][N:11]([CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27347582-(2,3-dichlorophenyl)ethanamineHCID 67319255HCID 67319255, 화합물

생성물 1

HCID 59263843HCID 59263843, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-((Benzyloxycarbonyl)(3,4-dichlorophenethyl)amino)propanoic acid (0.5 g), prepared according to the procedure of Example 1 step iv), but using 2,3-dichlorophenethylamine instead of phenethylamine, was dissolved in dichloromethane (10 mL) and treated with oxalyl chloride (0.132 mL) and DMF (0.05 mL). The reaction was stirred at room temperature until gas evolution ceased, and the solvent was removed in vacuo to give an oil which was used in step ii) directly.

후처리

  1. customthe solvent was removed in vacuo
  2. customto give an oil which

출처 및 근거

ORD 기록
ord-1c63868baad64cccadc8b6c327d2bca9
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700782B2

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