Bicyclo(2.2.1)heptane-2-methanol → gamma-benzyl-L-glutamic acid gamma-2-norbornylmethyl-L-glutamic acid

반응식

[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[CH2:8]O.[NH2:10][C@H:11]([C:17]([OH:19])=[O:18])[CH2:12][CH2:13][C:14]([OH:16])=[O:15].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>ClCCCl>[CH2:7]([CH:13]([C:14]([OH:16])=[O:15])[CH2:12][C@@H:11]([C:17]([OH:19])=[O:18])[NH2:10])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[CH2:8][CH:13]([C:14]([OH:16])=[O:15])[CH2:12][C@@H:11]([C:17]([OH:19])=[O:18])[NH2:10]

참가 물질

실험 절차

By a method similar to that of Synthetic Example 4, poly-γ-benzyl-L-glutamic acid was obtained and dissolved in 1,2-dichloroethane. Thereto were added an equivalent amount of norbornane-2-methanol (manufactured by Tokyo Chemical Industry Co., Ltd.) relative to the glutamic acid unit of poly-γ-benzyl-L-glutamic acid and a catalytic amount of p-toluenesulfonic acid monohydrate, and the mixture was stirred at 65° C. for 4 days to give a γ-benzyl-L-glutamic acid/γ-2-norbornylmethyl-L-glutamic acid copolymer. The weight average molecular weight, Mw, of the obtained copolymer was measured by Measurement Method 1 described below. In addition, the composition of the polymer after transesterification reaction was measured by Measurement Method 2 described below.