Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methylindole → 5-Methylindoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methylindole | HCID 11978 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 5-methoxy-2,3-dihydro-1H-indole | HCID 10701974 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-Methylindoline | HCID 14023679 | 99% |
반응 단계
5-Methylindoline was prepared from 5-methylindole using the procedure described for the preparation of 5-methoxyindoline. 5-Methylindole (11 g, 0.0835 mol) in glacial acetic acid (150 mL) in a 1 L 3-necked flask was reduced at 10-15° C. with sodium cyanoborohydride (15.8 g, 0.251 mol). Extraction with ethyl acetate provided 5-methylindoline (11 g, 0.0832 mol, 99% yield) as a thick oil which was used without further purification. The structure was corroborated by NMR spectroscopy.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07704667B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-d01d4c3cbc214279923b9c09f839446b |
| 출처 메모 | uspto-grants-2010_04 |