Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → 8-Boc-3,8-diaza-bicyclo(3.2.1)octane

HRID 645351

반응식

HRID 645351 반응식
[C:1]([O:5][C:6]([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][N:11](CC1C=CC=CC=1)[CH2:12]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH:9]2[CH2:15][CH2:14][CH:13]1[CH2:12][NH:11][CH2:10]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 15740907Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

생성물 1

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octane

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 3-benzyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (13.0 g, 43.0 mmol), palladium on carbon (4.0 g, 5%) and ethanol (100 ml, 99%) was stirred under hydrogen. The mixture was filtered on celite, dried and evaporated. A white powder was isolated. Yield 8.4 g (92%). Mp 103.4-106° C.

후처리

  1. filtrationThe mixture was filtered on celite
  2. customdried
  3. customevaporated
  4. customA white powder was isolated

출처 및 근거

ORD 기록
ord-22b8c09f52dd4a4584e4577c0b55a3a0
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704991B2

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