Ammonia → 2-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline

HRID 645352노트

반응식

HRID 645352 반응식
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][N:11]([C:16]1[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N+:26]([O-:28])=[O:27])[CH:22]=3)[N:17]=1)[CH2:12]2)=O)(C)(C)C.FC(F)(F)C(O)=O.N>ClCCl>[CH:13]12[NH:8][CH:9]([CH2:15][CH2:14]1)[CH2:10][N:11]([C:16]1[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N+:26]([O-:28])=[O:27])[CH:22]=3)[N:17]=1)[CH2:12]2

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 686830833-(6-Nitro-quinolin-2-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic Acid Tert-Butyl Ester

생성물 1

HCID 119507832-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 3-(6-nitro-quinolin-2-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.0 g, 2.6 mmol), trifluoroacetic acid (2.97 g, 26.0 mmol) and dichloromethane (10 ml) was stirred for 15 h. The mixture was made alkaline by adding concentrated ammonia. The mixture was extracted with dichloromethane, dried and evaporated. Yield 0.50 g (90%) Mp 185° C. decomp.

후처리

  1. extractionThe mixture was extracted with dichloromethane
  2. customdried
  3. customevaporated

출처 및 근거

ORD 기록
ord-5da7f429d1c04681b8419faefc4a3a8b
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704991B2

반응 노트

불러오는 중…