Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tropic acid → 3-Hydroxy-2-phenyl-1-pyrrolidin-1-yl propan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tropic acid | HCID 10726 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | HOAt | HCID 181649 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Hydroxy-2-phenyl-1-pyrrolidin-1-yl propan-1-one | HCID 68706980 | — |
반응 단계
To a solution of tropic acid (0.12 mmol) and pyrrolidine (0.12 mmol) in DMF (20 mL) are added HOAt (0.18 mmol) and EDCI-HCl (0.18 mmol). The reaction mixture is stirred at room temperature for 14 h. The reaction mixture is diluted with water, then extracted with AcOEt. The organic extracts are successively washed with water, sat. aq, NaHCO3, H2O and brine, dried over Na2SO4, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography to give 3-hydroxy-2-phenyl-1-pyrrolidin-1-yl propan-1-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07704996B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-15157d95db1648df88d50d6902912257 |
| 출처 메모 | uspto-grants-2010_04 |