Tetrahydrofuran → 2,4-Dichloro-5-pyrimidinecarboxylic acid

HRID 645509

반응식

HRID 645509 반응식
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9](Cl)=[O:10])=[CH:4][N:3]=1.C1C[O:15]CC1>O>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9]([OH:10])=[O:15])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 8028TetrahydrofuranHCID 137841122,4-Dichloropyrimidine-5-carbonyl chloride

생성물 1

HCID 219418962,4-Dichloro-5-pyrimidinecarboxylic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a solution of the 2,4-dichloropyrimidine-5-carbonyl chloride (24 mmol) in THF (24 mL) is added H2O (0.64 mL) at room temperature. The reaction mixture is stirred at room temperature for 0.83 h and then diluted with H2O. The mixture is extracted with AcOEt. The organic extracts are washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo to give the crude titled compound; 1H NMR (CDCl3) δ 6.80 (brs, 1H), 9.18 (s, 1H).

후처리

  1. extractionThe mixture is extracted with AcOEt
  2. washThe organic extracts are washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-a6d60d2669694752a24f9d7362b9c7a5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704996B2

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