Thionyl Chloride → 3-(Azidomethyl)-2-chloro-5-fluoropyridine

HRID 645579노트

반응식

HRID 645579 반응식
[Cl:1][C:2]1[C:7]([CH2:8]O)=[CH:6][C:5]([F:10])=[CH:4][N:3]=1.S(Cl)(Cl)=O.[N-:15]=[N+:16]=[N-:17].[Na+]>>[N:15]([CH2:8][C:7]1[C:2]([Cl:1])=[N:3][CH:4]=[C:5]([F:10])[CH:6]=1)=[N+:16]=[N-:17]

참가 물질

4

반응물 3

HCID 24386Thionyl ChlorideHCID 33557Sodium AzideHCID 24229204(2-Chloro-5-fluoropyridin-3-yl)methanol

생성물 1

HCID 860822623-(Azidomethyl)-2-chloro-5-fluoropyridine

실험 절차

(2-chloro-5-fluoro-pyridin-3-yl)-methanol, thionyl chloride and sodium azide were processed according to the method of Example 115A to provide the product. MS (ESI+) m/z 187 (M+H)+.

후처리

  1. customto provide the product

출처 및 근거

ORD 기록
ord-b18cb80817c3454788529220417006d5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704997B1

반응 노트

불러오는 중…