Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methoxyphenylboronic acid → 2-(2-Methoxy-phenyl)-6-trifluoromethyl-nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methoxyphenylboronic acid | HCID 2733958 | — |
| 반응물 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile | HCID 2778413 | — |
| 생성물 | 2-(2-Methoxy-phenyl)-6-trifluoromethyl-nicotinonitrile | HCID 68582487 | 91% |
반응 단계
Prepared in 91% yield from 2-chloro-6-trifluoromethylnicotinonitrile and 2-methoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 279.0 (M+H)+; 1H NMR (CDCl3) δ 3.83 (s, 3H), 7.15 (dd, J=7.5, 7.5 Hz, 1H), 7.25 (d, J=7.8 Hz, 1H), 7.43 (dd, J=7.4, 1.7 Hz, 1H), 7.55-7.63 (m, 2H), 8.12 (d, J=8.1 Hz, 1H), 8.71 (d, J=7.5 Hz, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07704997B1 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-38faf2c74dc147e1a3119d27a3c064e0 |
| 출처 메모 | uspto-grants-2010_04 |