2-Chloronicotinonitrile → HCID 68582093, 화합물

HRID 645628노트

반응식

HRID 645628 반응식
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:12]=1B(O)O>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[C:13]([O:17][CH3:18])[CH:12]=1

참가 물질

3

반응물 2

HCID 810792-ChloronicotinonitrileHCID 3294524(2-Fluoro-6-methoxyphenyl)boronic acid

생성물 1

HCID 68582093HCID 68582093, 화합물수율 85%

실험 절차

Prepared in 85% yield from 2-chloronicotinonitrile and 2-fluoro-6-methoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 228.9 (M+H)+; 1H NMR (CDCl3) δ 6.82-6.88 (m, 2H), 7.38-7.46 (m, 2H), 8.07 (dd, J=7.8, 1.7 Hz, 1H), 8.91 (dd, J=4.9, 1.9 Hz, 1H).

출처 및 근거

ORD 기록
ord-dd0f35bd187544498334103ffc8ea09f
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704997B1

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