Sulfanilamide → 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide

참여 물질

역할	이름	HCID	투입량
반응물	Sulfanilamide	HCID 5333	—
반응물	Chlorotrimethylsilane	HCID 6397	—
반응물	2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	HCID 86628035	—
용매	1-Butanol	HCID 263	—
생성물	4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide	HCID 68579482	56.3%

반응 조건

온도	116 °C

반응 단계

A mixture of 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (150 mg, 0.34 mmol), sulfanilamide (125 mg, 0.73 mmol) and trimethylsilyl chloride (TMSCl) (0.100 mL, 0.79 mmol) inn-butyl alcohol (4 mL) was heated at 116° C. for 96 h. The mixture was then purified by HPLC to give 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide (110 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705004B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-f6a5d8a5e86a40c593b6ebf333a30396
출처 메모	uspto-grants-2010_04