1H-Indazol-6-amine → 2-chloro-N-(1H-indazol-6-yl)-5-iodo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

참여 물질

역할	이름	HCID	투입량
반응물	1H-Indazol-6-amine	HCID 81423	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	2,4-dichloro-5-iodo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	HCID 57990293	—
용매	1-Butanol	HCID 263	—
생성물	2-chloro-N-(1H-indazol-6-yl)-5-iodo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	HCID 86628040	60.9%

반응 조건

온도	45 °C

반응 단계

To a mixture of 2,4-dichloro-5-iodo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (1.5 g, 3.2 mmol) in n-butyl alcohol (12 mL) was added 6-aminoindazole (0.47 g, 3.52 mol) and DIPEA (0.86 mL, 4.80 mmol). After heating at 45° C. for 15 h, the mixture was cooled to room temperature, and the resulting precipitates were collected by filtration to give 2-chloro-N-(1H-indazol-6-yl)-5-iodo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1.1 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705004B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-a93399419ff6477086166b7e7980ff53
출처 메모	uspto-grants-2010_04