N,N-dimethyl-2-(piperazin-1-yl)acetamide → cis-2-{4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide

참여 물질

역할	이름	HCID	투입량
반응물	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
반응물	4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613626	—
생성물	cis-2-{4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide	HCID 24774973	—

반응 단계

cis-4-[4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 8) was reacted with N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) to give cis-2-{4-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C32H37N7O4Cl2 [(M+H)+] 654.2357, observed 654.2355.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705007B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-bf09582dc09545f1a3b257652ef97c18
출처 메모	uspto-grants-2010_04