1-(2-Methanesulfonylethyl)piperazine dihydrochloride → cis-[4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone

참여 물질

역할	이름	HCID	투입량
반응물	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
반응물	4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613626	—
생성물	cis-[4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone	HCID 24774974	—

반응 단계

cis-4-[4,5-Bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 8) was reacted with 1-(2-methanesulfonylethyl)-piperazine dihydrochloride (example 3) to give cis-[4,5-bis-(4-chloro-phenyl)-2-(2,4-diethoxy-pyrimidin-5-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C31H37N6O5SCl2 [(M+H)+] 675.1918, observed 675.1914.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705007B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-5491314d9a4d40a8b1927deef9808cd5
출처 메모	uspto-grants-2010_04