1-Methylpiperazine → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone

참여 물질

역할	이름	HCID	투입량
반응물	1-Methylpiperazine	HCID 53167	—
반응물	2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613632	—
생성물	cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone	HCID 24775345	—

반응 단계

cis-4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-methyl-piperazine (Aldrich) to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C32H37N6O2Cl2 [(M+H)+] 595.2350, observed 595.2351.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705007B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-7bb62ee38e3e417eb05f313e0805085b
출처 메모	uspto-grants-2010_04