1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

참여 물질

역할	이름	HCID	투입량
반응물	1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride	HCID 49853479	—
반응물	2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613632	—
생성물	cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone	HCID 24775346	—

반응 단계

cis-4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-(3-methanesulfonyl-propyl)-piperazine dihydrochloride to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C34H43N6O4SCl2 [(M+H)+] 701.2438, observed 701.2439.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705007B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-6b63cc057b01400f92c3376302875349
출처 메모	uspto-grants-2010_04