Potassium Hydroxide → 2-{4-[(Quinoxalin-2-yl)oxy]phenoxy}propanoic acid

HRID 64576

반응식

HRID 64576 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:24]=[CH:23][C:15]([O:16][CH:17]([CH3:22])[C:18]([O:20]C)=[O:19])=[CH:14][CH:13]=1.[OH-].[K+]>O.CO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:13]=[CH:14][C:15]([O:16][CH:17]([CH3:22])[C:18]([OH:20])=[O:19])=[CH:23][CH:24]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 187099Methyl 2-(4-(2-quinoxalinyloxy)phenoxy)propanoate

생성물 1

HCID 136705312-{4-[(Quinoxalin-2-yl)oxy]phenoxy}propanoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

3.2 g (0.01 mole) Methyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate was added to a solution of 0.7 g (0.01 mole) potassium hydroxide in 5 cc water and 60 cc methanol. The mixture was stirred at room temperature overnight and then filtered to remove a small amount of insoluble material. The methanol was removed under vacuum. Ice and hydrochloric acid were added to the mixture until it was acidic (pH~2). The precipitated acid was filtered and purified by redissolution into saturated sodium bicarbonate solution, reprecipitation by acidification with dilute hydrochloric acid and crystallization from methanol. Yield 0.7 g, m.p. 137°-141°.

후처리

  1. filtrationfiltered
  2. customto remove a small amount of insoluble material
  3. customThe methanol was removed under vacuum
  4. additionIce and hydrochloric acid were added to the mixture until it
  5. filtrationThe precipitated acid was filtered
  6. custompurified by redissolution into saturated sodium bicarbonate solution, reprecipitation by acidification with dilute hydrochloric acid and crystallization from methanol

출처 및 근거

ORD 기록
ord-ac1ce241150440a9bab18cfbd19acab5
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609396

연결된 노트

불러오는 중…