N,N-Bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride → 2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamide

참여 물질

역할	이름	HCID	투입량
반응물	N,N-Bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride	HCID 67246429	—
반응물	cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613636	—
생성물	2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamide	HCID 24775527	—

반응 단계

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 34) was reacted with N,N-bis-(2-methoxy-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride to give 2-(4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-bis-(2-methoxy-ethyl)-acetamide in an analogous manner as described in example 1. LR-MS: 702.3 [(M+H)+]

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07705007B2
출처 데이터셋	uspto-grants-2010_04
ORD ID	ord-0485a562b9ea4252b9817229b2604aa9
출처 메모	uspto-grants-2010_04