Diethylamine → N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide

HRID 64578

반응식

HRID 64578 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH:17]([CH3:21])[C:18](Cl)=[O:19])=[CH:14][CH:13]=1.[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>C(Cl)Cl>[CH2:24]([N:26]([CH2:27][CH3:28])[C:18](=[O:19])[CH:17]([O:16][C:15]1[CH:22]=[CH:23][C:12]([O:11][C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)=[CH:13][CH:14]=1)[CH3:21])[CH3:25]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 136705322-[4-(2-Quinoxalinyloxy)phenoxy]propionyl chloride

생성물 1

HCID 13670533N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The title compound can be prepared by interaction of 2-[4-(2-quinoxalinyloxy)phenoxy]propionic acid with thionyl chloride in a suitable solvent such as chlorobutane. Add a solution of 3.3 g (0.01 mole) 2-[4-(2-quinoxalinyloxy)phenoxy]propionyl chloride in 30 cc methylene chloride to a cold (5° C.) solution of 1.8 g (0.025 mole) diethylamine in 30 cc methylene chloride. Stir the mixture at room temperature overnight. Wash the methylene chloride solution with water and dry over magnesium sulfate. Remove the methylene chloride under vacuum to yield N,N-diethyl-2-[4-(quinoxalinyloxy)phenoxy]propanamide.

후처리

  1. washWash the methylene chloride solution with water
  2. dry with materialdry over magnesium sulfate
  3. customRemove the methylene chloride under vacuum

출처 및 근거

ORD 기록
ord-7b160d66813745f18aafc58f5939045e
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609396

연결된 노트

불러오는 중…