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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Cyclopropylamine → 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-cyclopropyl-3-pyridinecarboxamide

HRID 645841
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HRID 645841 반응식
[C:1]([C:8]1NC=CN=1)([C:3]1[NH:4]C=CN=1)=O.[CH:13]1([N:17]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][C:26]([O:28][C:29]4[N:34]=[CH:33][C:32]([C:35]([OH:37])=O)=[CH:31][CH:30]=4)=[CH:27][C:20]=3[CH2:19][CH2:18]2)[CH2:16][CH2:15][CH2:14]1.C1(N)CC1>ClCCl>[CH:13]1([N:17]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][C:26]([O:28][C:29]4[N:34]=[CH:33][C:32]([C:35]([NH:4][CH:3]5[CH2:1][CH2:8]5)=[O:37])=[CH:31][CH:30]=4)=[CH:27][C:20]=3[CH2:19][CH2:18]2)[CH2:14][CH2:15][CH2:16]1
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참가 물질

5

반응물 3

HCID 69828CyclopropylamineHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 103150776-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarboxylic acid

생성물 1

HCID 104072536-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-cyclopropyl-3-pyridinecarboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Carbonyl diimidazole (142 mg, 0.88 mmol) was added to a stirred solution of 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-3-pyridinecarboxylic acid (E196b) (150 mg, 0.44 mmol) in dichloromethane (5 ml). After stirring at room temperature for 3 hours, cyclopropylamine (0.15 ml, 2.2 mmol) was added and the mixture was allowed to stir for a further 18 hours. The reaction mixture was applied to a SCX ion cartridge (Varian bond-elute, 10 g) and washed with methanol and then a mixture of 0.880 ammonia:methanol (1:9). The combined basic fractions were concentrated in vacuo to afford the title compound (E196). MS (ES+) m/e 378 [M+H]+.

후처리

  1. stirringto stir for a further 18 hours
  2. washwashed with methanol
  3. additiona mixture of 0.880 ammonia:methanol (1:9)
  4. concentrationThe combined basic fractions were concentrated in vacuo

출처 및 근거

ORD 기록
ord-3b3cf5861ce746d2a661b5140429b5e8
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07704994B2

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