HCID 18449044, 화합물 → 4-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde

HRID 645956노트

반응식

HRID 645956 반응식
[F:1][CH:2]([F:21])[O:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][CH:10]=2)[N:7]=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:5]=1>C(Cl)Cl.O=[Mn]=O>[F:21][CH:2]([F:1])[O:3][C:4]1[N:8]([C:9]2[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[CH:13][CH:14]=2)[N:7]=[C:6]([C:17]([F:20])([F:19])[F:18])[CH:5]=1

참가 물질

4

반응물 1

HCID 18449044HCID 18449044, 화합물

생성물 1

HCID 184490424-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde수율 95.3%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of [4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-phenyl]-methanol (380 mg, 1.2 mmol) in DCM (20 mL) was treated with excess amount of MnO2 was stirred at room temperature for 24 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by chromatography (SiO2, 6:1 hexane/EtOAc) gave 4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde (350 mg, 93% yield) as a syrup.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPurification by chromatography (SiO2, 6:1 hexane/EtOAc)

출처 및 근거

ORD 기록
ord-9ae11630f6454ecda731d98dd5ccfd55
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705029B2

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