Benzaldehyde → 2-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enone

HRID 646060

반응식

[CH3:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5](=[O:6])[CH2:4][C:3]1=[O:7].[CH:14](=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=2)[NH:25][CH:24]=1>>[CH3:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=2)[NH:25][C:24]=1[CH:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4]1[C:3](=[O:7])[C:2]([CH3:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]=1[OH:6]

참가 물질

반응물 3

HCID 240Benzaldehyde

HCID 986153,5-Dimethylindole

HCID 685810272-Methyl-2-phenyl-cyclobutane-1,3-dione

생성물 1

HCID 250508792-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enone

실험 절차

Using general procedure C, 2-methyl-2-phenyl-cyclobutane-1,3-dione (Lit. 1) was reacted with benzaldehyde and 3,5-dimethyl-1H-indole (Lit. 3) to give the title compound as a colorless solid. MS: 406.5 ([M−H]−).

출처 및 근거

ORD 기록: ord-2aedb6d4798f470892b895736560a396
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07705034B2

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