Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 반응물 | 2-Chloro-3-nitropyrazine | HCID 15914235 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol | HCID 15914239 | — |
반응 단계
To a solution of 1.5 g (0.0094 mol) 3 and 1.01 g (0.01 mol) triethylamine in 25 ml isopropanol is added 0.91 g (0.01 mol) 3-amino-1,2-propanediol (10). The reaction mixture becomes reddish and is stirred at room temperature for 16 hours. The solvent is then removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel to afford pure 11 as a yellow solid, m.p. 100°-102°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04609659 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-823de0febb72478ca27925ee6def8ecd |
| 출처 메모 | uspto-grants-1986_09 |