Triethylamine → 3-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

HRID 64610

반응식

HRID 64610 반응식
Cl[C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C(N(CC)CC)C.[NH2:18][CH2:19][CH:20]([OH:23])[CH2:21][OH:22]>C(O)(C)C>[OH:23][CH:20]([CH2:21][OH:22])[CH2:19][NH:18][C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 735613-Amino-1,2-propanediolHCID 159142352-Chloro-3-nitropyrazine

생성물 1

HCID 159142393-[(3-Nitro-2-pyrazinyl)amino]-1,2-propanediol

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a solution of 1.5 g (0.0094 mol) 3 and 1.01 g (0.01 mol) triethylamine in 25 ml isopropanol is added 0.91 g (0.01 mol) 3-amino-1,2-propanediol (10). The reaction mixture becomes reddish and is stirred at room temperature for 16 hours. The solvent is then removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel to afford pure 11 as a yellow solid, m.p. 100°-102°.

후처리

  1. customThe solvent is then removed on the rotary evaporator
  2. customthe residue is purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-823de0febb72478ca27925ee6def8ecd
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609659

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