Sodium Methoxide → Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylate

HRID 646114노트

반응식

HRID 646114 반응식
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([OH:32])=[O:31])=[CH:14]3)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].C[O-].[Na+:35]>C1COCC1>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([C:20]2[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=2)[C:15]([C:30]([O-:32])=[O:31])=[CH:14]3)=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[Na+:35]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 686968775-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid

생성물 1

HCID 68702464Sodium 5-(4-isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylate수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5-(4-Isopropoxyphenyl)-1-(2-naphthyl)indole-2-carboxylic acid (40 mg, 0.095 mmol; see Example 18) was dissolved in dry THF (1 mL) and NaOMe (3.37 M, 28 μL) was added via syringe. After stirring for 30 min at room temperature, the solvents were removed under reduced pressure and the residue dried in vacuo to yield the title compound (42 mg, 99%).

후처리

  1. customthe solvents were removed under reduced pressure
  2. customthe residue dried in vacuo

출처 및 근거

ORD 기록
ord-fec5dbf52c024ac3929f3149fc571cb6
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705023B2

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