Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 반응물 | Methyl 6-chloro-3-nitropyrazine-2-carboxylate | HCID 15914238 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate | HCID 15914243 | — |
반응 단계
To 1.0 g (0.004 mol) 9 in 15 ml isopropanol is added 0.36 g (0.004 mol) 10 and 0.4 g (0.004 mol) triethylamine at room temperature. The reaction mixture becomes reddish in color and is stirred at room temperature for 16 hours. The solvent is removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel followed by elution with 10% methanol/chloroform. Pure 15 has Rf 0.4 and is obtained as a yellow solid, m.p. 107°-9°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04609659 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-454a61fe3d5d40748003eece1dae88cf |
| 출처 메모 | uspto-grants-1986_09 |