Triethylamine → Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate

HRID 64612

반응식

HRID 64612 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([N+:12]([O-:14])=[O:13])=[N:4][CH:3]=1.[NH2:15][CH2:16][CH:17]([OH:20])[CH2:18][OH:19].C(N(CC)CC)C>C(O)(C)C>[OH:20][CH:17]([CH2:18][OH:19])[CH2:16][NH:15][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([N+:12]([O-:14])=[O:13])=[N:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 735613-Amino-1,2-propanediolHCID 15914238Methyl 6-chloro-3-nitropyrazine-2-carboxylate

생성물 1

HCID 15914243Methyl 6-[(2,3-dihydroxypropyl)amino]-3-nitropyrazine-2-carboxylate

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To 1.0 g (0.004 mol) 9 in 15 ml isopropanol is added 0.36 g (0.004 mol) 10 and 0.4 g (0.004 mol) triethylamine at room temperature. The reaction mixture becomes reddish in color and is stirred at room temperature for 16 hours. The solvent is removed on the rotary evaporator and the residue is purified by flash chromatography on silica gel followed by elution with 10% methanol/chloroform. Pure 15 has Rf 0.4 and is obtained as a yellow solid, m.p. 107°-9°.

후처리

  1. customThe solvent is removed on the rotary evaporator
  2. customthe residue is purified by flash chromatography on silica gel
  3. washfollowed by elution with 10% methanol/chloroform
  4. customis obtained as a yellow solid, m.p. 107°-9°

출처 및 근거

ORD 기록
ord-454a61fe3d5d40748003eece1dae88cf
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609659

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