참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| 반응물 | 2-(o-Tolyl)acetonitrile | HCID 31155 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 11564718 | HCID 11564718 | 30.5% |
반응 단계
A thick walled tube was charged with 1H-pyrrole-2-carbaldehyde (2.0 g, 21.0 mmol), 2-methylphenylacetonitrile (2.5 g, 18.9 mmol, 0.9 equivalents), ethanol (75 ml), and 40% aqueous Triton B (4.0 ml, 3.3 mmol). The tube was sealed and heated to 90° C. for 4 days. Removal of the solvent, followed by chromatography on silica gel using dichloromethane/petroleum spirits (20:80) as eluant afforded a yellow solid (1.2 g). This is Compound 16 in Table 8.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07705038B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_04 |
|---|
| ORD ID | ord-f0f6894a5e0e45489252798d02e21b8b |
|---|
| 출처 메모 | uspto-grants-2010_04 |
|---|
