Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 1-(Difluoromethoxy)-4-ethynylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | {[4-(Difluoromethoxy)phenyl]ethynyl}(trimethyl)silane | HCID 68699091 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Diethylether hexane | HCID 21584099 | — |
| 생성물 | 1-(Difluoromethoxy)-4-ethynylbenzene | HCID 2778497 | 97% |
반응 단계
A solution of {[4-(difluoromethoxy)phenyl]ethynyl}(trimethyl)silane (10.0 g, 41.7 mmol) in MeOH/CH2Cl2 (1/1) was treated with cesium carbonate (16.3 g, 50 mmol) at room temperature, stirred for 1.5 h, diluted with CH2Cl2 and filtered through a pad of silica gel. The filtrate was concentrated to dryness to give the title compound (6.8 g, 97%) as an oil, identified by NMR and mass spectral analyses. MS (+) EI:168.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07705030B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-d89efcc5184c4c30883d065eed3cf3bf |
| 출처 메모 | uspto-grants-2010_04 |