Water → 4-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

HRID 64633노트

반응식

HRID 64633 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH:16]([CH:19]=O)[CH:17]=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH2:21][NH2:22].O>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]1[CH:19]=[N:21][NH:22][CH:17]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9321HydrazineHCID 54388185HCID 54388185, 화합물

생성물 1

HCID 136726874-[(2,4-Dichlorophenyl)phenylmethyl]-1H-pyrazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Two grams of [(2,4-dichlorophenyl)phenylmethyl]malonaldehyde in 10 ml of ethanol were heated with 3 ml of anhydrous hydrazine on a steam bath for two hours. The reaction mixture was poured into water and extracted with ether. The ether extract was dried, filtered, and evaporated. The residue was crystallized twice from Skelley B/acetone to provide 1.2 g of the desired title product, m.p. 131° C.

후처리

  1. extractionextracted with ether
  2. extractionThe ether extract
  3. customwas dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized twice from Skelley B/acetone

출처 및 근거

ORD 기록
ord-cb337b6c2bb44925af26f18ccc8fd109
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609666

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