(5-Acetylthiophen-2-yl)boronic acid → 1-{5-[4-((S)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-thiophen-2-yl}-ethanone

HRID 646434노트

반응식

HRID 646434 반응식
[C:1]([C:4]1[S:8][C:7](B(O)O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[N:12]1([CH2:17][CH:18]2[CH2:22][CH2:21][CH2:20][N:19]2[C:23]([C:25]2[CH:30]=[CH:29][C:28](Br)=[CH:27][CH:26]=2)=[O:24])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([CH2:17][C@@H:18]2[CH2:22][CH2:21][CH2:20][N:19]2[C:23]([C:25]2[CH:26]=[CH:27][C:28]([C:7]3[S:8][C:4]([C:1](=[O:3])[CH3:2])=[CH:5][CH:6]=3)=[CH:29][CH:30]=2)=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16]1

참가 물질

3

반응물 2

HCID 4143377(5-Acetylthiophen-2-yl)boronic acidHCID 11964813(4-Bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone

생성물 1

HCID 116466491-{5-[4-((S)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-thiophen-2-yl}-ethanone

실험 절차

The title compound is prepared in a manner substantially analogous to Procedure Q starting from 5-Acetyl-2-thiophene boronic acid and 4-(2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl bromide to give 42 mg (37%). MS (ES+) 383.2

후처리

  1. customto give 42 mg (37%)

출처 및 근거

ORD 기록
ord-0fa13721827b4c289bbde79f6f506ebc
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705025B2

반응 노트

불러오는 중…