1-Methylimidazole → HCID 70387753, 화합물

HRID 64654

반응식

HRID 64654 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>C(OCC)C>[Br-:1].[CH3:13][NH+:14]1[CH:18]=[CH:17][N:16]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=2)=[O:4])[CH2:15]1

참가 물질

4

반응물 2

HCID 13901-MethylimidazoleHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

생성물 1

HCID 70387753HCID 70387753, 화합물수율 38.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 4.41 g (0.019 mol) of 1-bromo-2-(4-ethylphenyl)-2-oxoethane and 1.65 g (0.02 mol) of 1-methylimidazole in 40 ml of diethyl ether was stirred at room temperature for approximately 18 hours. The reaction solvent was decanted, and the residue was washed with diethyl ether and dissolved in a small amount of acetonitrile. The resulting solution was diluted with a small amount of ethyl acetate, whereupon a brown precipitate formed. The solid was collected and recrystallized from acetonitrile/ethyl acetate to provide 2.26 g of 1-methyl-3-[2-(4-ethylphenyl)-2-oxoethyl]-1H-imidazolium bromide as fine yellow brown needles. (38% yield) mp=177°-179° C.

후처리

  1. customThe reaction solvent was decanted
  2. washthe residue was washed with diethyl ether
  3. dissolutiondissolved in a small amount of acetonitrile
  4. additionThe resulting solution was diluted with a small amount of ethyl acetate, whereupon a brown precipitate
  5. customformed
  6. customThe solid was collected
  7. customrecrystallized from acetonitrile/ethyl acetate

출처 및 근거

ORD 기록
ord-124ab2184a4f4cee8b6314db4d3d9224
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609670

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