1-Methylimidazole → 1-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide

HRID 64656

반응식

HRID 64656 반응식
[C:1]1([C:7](=[O:11])[CH:8]([Br:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1>C(OCC)C>[Br-:10].[CH3:12][NH+:13]1[CH:17]=[CH:16][N:15]([CH:8]([CH3:9])[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:11])[CH2:14]1

참가 물질

4

반응물 2

HCID 13901-MethylimidazoleHCID 164522-Bromopropiophenone

생성물 1

HCID 703877441-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide수율 55%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 8 ml (0.047 mol) of 90% pure 1-phenyl-1-oxo-2-bromopropane and 4.25 g (0.052 mol) of 1-methylimidazole in 100 ml of diethyl ether was stirred at room temperature for approximately 24 hours. The precipitated solid was collected by filtration, washed with diethyl ether and dissolved in methanol. This solution was diluted with diethyl ether and the resulting white solid was collected by filtration. This solid was recrystallized from methanol/diethyl ether to afford 7.65 g of 1-methyl-3-(1-methyl-2-phenyl-2-oxoethyl)-1H-imidazolium bromide as white crystals. (55% yield) mp=167°-170° C.

후처리

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with diethyl ether
  3. dissolutiondissolved in methanol
  4. additionThis solution was diluted with diethyl ether
  5. filtrationthe resulting white solid was collected by filtration
  6. customThis solid was recrystallized from methanol/diethyl ether

출처 및 근거

ORD 기록
ord-adb1937ba43f4ec58485f7a79e1b4121
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609670

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