1-Methylimidazole → 1-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide

HRID 64659

반응식

HRID 64659 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1>C(OCC)C>[Br-:1].[CH3:12][NH+:13]1[CH:17]=[CH:16][N:15]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=2)=[O:4])[CH2:14]1

참가 물질

4

반응물 2

HCID 13901-MethylimidazoleHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

생성물 1

HCID 703875941-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide수율 25%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 5.16 g (0.024 mol) of 1-bromo-2-(3-methylphenyl)-2-oxoethane and 2.15 g (0.026 mol) of 1-methylimidazole in approximately 30 ml of diethyl ether was stirred at room temperature for about 19 hours. The reaction solvent was decanted and the resulting brown residue was washed with diethyl ether. The residue was washed with hot acetonitrile and recrystallized twice from acetonitrile/diethyl ether to afford 1.74 g of 1-methyl-3-[2-(3-methylphenyl)-2-oxoethyl]-1H-imidazolium bromide as white needles. (25% yield) mp=185°-187° C.

후처리

  1. customThe reaction solvent was decanted
  2. washthe resulting brown residue was washed with diethyl ether
  3. washThe residue was washed with hot acetonitrile
  4. customrecrystallized twice from acetonitrile/diethyl ether

출처 및 근거

ORD 기록
ord-5f078ae1843a466bba893ce12b967e2a
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609670

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