1,2-Ethanediamine, N1-phenyl- → 3-amino-N-methyl-6-[3-({[2-(phenylamino)ethyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide
반응식
[C:1]1([NH:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[N:13]=[CH:14][C:15]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25](O)=[O:26])=[N:16][C:17]=1[C:18]([NH:20][CH3:21])=[O:19]>>[NH2:11][C:12]1[C:17]([C:18]([NH:20][CH3:21])=[O:19])=[N:16][C:15]([C:22]2[CH:30]=[CH:29][CH:28]=[C:24]([C:25]([NH:10][CH2:9][CH2:8][NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:26])[CH:23]=2)=[CH:14][N:13]=1참가 물질
3
실험 절차
3-amino-N-methyl-6-[3-({[2-(phenylamino)ethyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide was synthesized according to the procedure described in above from N-phenylethane-1,2-diamine and 3-{5-amino-6-[(methylamino)carbonyl]pyrazine-2-yl}benzoic acid. Yield 45%: 1H NMR (400 MHz, CDCl3): 8.90 (s, 1H), 8.82 (br d, 1H), 8.70 (br t, 1H), 8.45 (br s, 1H), 8.32 (br d, 1H), 7.82 (br d, 1H), 7.52 (t, 1H), 7.02 (t, 2H), 6.62 (d, 2H), 6.50 (t, 1H), 5.72 (br t, 1H), 3.52 (d, 2H), 3.20 (d, 2H), 2.92 (d, 3H); MS (EI) for C21H22N6O2: 391 (MH+)
출처 및 근거
- ORD 기록
- ord-95b5c7a9f13e45918b10f4d41905089b
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07704995B2
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