Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine → Ganciclovir
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine | HCID 136408871 | — |
| 용매 | Ammonia | HCID 222 | — |
| 생성물 | Ganciclovir | HCID 135398740 | 95.1% |
반응 단계
N2 -Acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine (721.9 mg, 2.4 mmol) was stirred with 50 ml of methanolic ammonia solution (methanol saturated with ammonia at 0° C.) for 17 hours at 21° C. The solution was concentrated to a white solid and the residue recrystallized from water or methanol to give 582.3 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, mp 250° C. d.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04609661 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-770c97fdc13a424cac774df6666fea09 |
| 출처 메모 | uspto-grants-1986_09 |