N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine → Ganciclovir

HRID 64670

반응식

HRID 64670 반응식
N#N.C([NH:6][C:7]1[NH:8][C:9](=[O:23])[C:10]2[N:11]=[CH:12][N:13]([CH2:16][O:17][CH:18]([CH2:21][OH:22])[CH2:19][OH:20])[C:14]=2[N:15]=1)(=O)C>N>[OH:20][CH2:19][CH:18]([O:17][CH2:16][N:13]1[CH:12]=[N:11][C:10]2[C:9](=[O:23])[NH:8][C:7]([NH2:6])=[N:15][C:14]1=2)[CH2:21][OH:22]

참가 물질

3

반응물 1

HCID 136408871N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine

생성물 1

HCID 135398740Ganciclovir수율 95.1%

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

N2 -Acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine (721.9 mg, 2.4 mmol) was stirred with 50 ml of methanolic ammonia solution (methanol saturated with ammonia at 0° C.) for 17 hours at 21° C. The solution was concentrated to a white solid and the residue recrystallized from water or methanol to give 582.3 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, mp 250° C. d.

후처리

  1. concentrationThe solution was concentrated to a white solid
  2. customthe residue recrystallized from water or methanol

출처 및 근거

ORD 기록
ord-770c97fdc13a424cac774df6666fea09
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609661

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