Ammonia → Aminopyrazine carboxamide

HRID 646732

반응식

HRID 646732 반응식
[NH2:1][C:2]1[C:3]([C:8]([O:10]C)=O)=[N:4][CH:5]=[CH:6][N:7]=1.[NH3:12]>CO>[NH2:1][C:2]1[C:3]([C:8]([NH2:12])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 72669Methyl 3-aminopyrazinecarboxylate

생성물 1

HCID 280292Aminopyrazine carboxamide수율 97.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
112.5 °C

실험 절차

A suspension of methyl 3-aminopyrazine-2-carboxylate (5 g, 32.6 mmol) and 150 mL of dry methanol saturated with anhydrous ammonia were heated in an autoclave at 110-115° C. for 24 h. Concentration and filtration afforded 3-aminopyrazine-2-carboxamide (4.4 g, 97.7% yield) as a yellow solid.

후처리

  1. concentrationConcentration and filtration

출처 및 근거

ORD 기록
ord-18874ded497546f18a4d5fbaeb33b899
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07704995B2

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