1,1-Dichloroacetone → 2-(4-(Chloromethyl)-4-hydroxy-2-thiazolin-2-yl)guanidine hydrochloride
반응식
[Cl:1][CH:2](Cl)[C:3](=[O:5])[CH3:4].[C:7]([NH:10][C:11]([NH2:13])=[S:12])(=[NH:9])[NH2:8]>CC(C)=O>[ClH:1].[Cl:1][CH2:2][C:3]1([OH:5])[CH2:4][S:12][C:11]([N:10]=[C:7]([NH2:9])[NH2:8])=[N:13]1참가 물질
4
실험 절차
60.0 kg of dichloroacetone is dissolved in 550 ml of acetone. After cooling the solution to -5°~7° C., 55.8 kg of (aminoiminomethyl)thiourea[amidinothiourea] is added to the solution under cooling portionwise at one hour intervals each time in a 10 kg amount of amidinothiourea. The mixture is stirred continuously for 5 days below 0° C. The resultant precipitates are collected by filtration, and washed with 50 l of acetone to provide 111.6 kg of the desired compound. This material can be used as the starting material for the next process.
후처리
- temperatureAfter cooling the solution to -5°~7° C.
- customThe resultant precipitates
- filtrationare collected by filtration
- washwashed with 50 l of acetone
출처 및 근거
- ORD 기록
- ord-b5eadab4dff149cfbd1d6decf374af6d
- 출처 데이터셋
- uspto-grants-1986_09
- 특허 번호
- US04609737
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