3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole → 5-[1-(Pyridin-3-yl)-1H-indol-3-yl]pentanoic acid

HRID 64683노트

반응식

HRID 64683 반응식
O=[C:2]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:10]=1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7]>C(O)(=O)C>[C:6]([CH2:5][CH2:4][CH2:3][CH2:2][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:10]=1)([OH:8])=[O:7]

참가 물질

3

반응물 1

HCID 136726973-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

생성물 1

HCID 134903525-[1-(Pyridin-3-yl)-1H-indol-3-yl]pentanoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 0.5 g of 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole in 7.5 ml of glacial acetic acid is added 0.5 g of borane-tert-butylamine complex. The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated, the residue is dissolved in 10 ml of 1N sodium hydroxide, water is added to the residue, the pH is adjusted to 5.0 with hydrochloric acid and the product is filtered off and dried to yield 3-(4-carboxybutyl)-N-(3-pyridyl)-indole identical to the compound obtained in Example 3b.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. dissolutionthe residue is dissolved in 10 ml of 1N sodium hydroxide
  3. additionwater is added to the residue
  4. filtrationthe product is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-a7924439a9494912a45e5d106a437e48
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609733

반응 노트

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