Morpholine → 4-[3-(4-Methyl-piperidin-1-yl)-4-nitro-phenyl)-morpholine

HRID 646856

반응식

Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]2)[CH:7]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[CH3:14][CH:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:7]=[C:2]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:3]=[CH:4][C:5]=2[N+:15]([O-:17])=[O:16])[CH2:9][CH2:10]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 586385011-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine

생성물 1

HCID 586385024-[3-(4-Methyl-piperidin-1-yl)-4-nitro-phenyl)-morpholine수율 106%

실험 절차

The procedure of Example 4, step (b) was followed using 304 mg (1.19 mmol) of 1-(5-chloro-2-nitro-phenyl)-4-methyl-piperidine (as prepared in the previous step) and 519 μL (5.95 mmol) of morpholine to afford 363 mg (106%) of the title compound as a yellow resin: Mass spectrum (ESI, m/z): Calcd. for C16H23N3O3, 306.2 (M+H), found 306.1.

출처 및 근거

ORD 기록: ord-18b973b3a3d74b5fa8c7b1308558b7b4
출처 데이터셋: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07705042B2

연결된 노트

불러오는 중…