Water → HCID 13120343, 화합물

HRID 64688

반응식

HRID 64688 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[OH-].[K+].O.Cl[CH2:13][CH:14]([OH:18])[CH2:15][CH2:16][Cl:17]>C(O)(C)C>[Cl:17][CH2:16][CH2:15][CH:14]([OH:18])[CH2:13][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1]

참가 물질

6

반응물 4

HCID 962WaterHCID 72452-ChlorophenolHCID 14797Potassium HydroxideHCID 170211,4-Dichloro-2-butanol

생성물 1

HCID 13120343HCID 13120343, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
50 °C

실험 절차

To a mixture of 129 g. (1 mole) of 2-chlorophenol, 60 g. of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 1.3 moles (185.9 g.) of 1,4-dichloro-2-butanol with stirring at 50° C. The resulting mixture was heated in a steam bath at 65° C. overnight and extracted with 300 ml. of isopropyl ether. The ether extract was washed successively with 1N sodium hydroxide, water and dried over sodium sulfate. The dried ether solution was concentrated and the oily residue was distilled under reduced pressure yielding 152 g. of an oily substance (b.p. 130°-131° C./0.01 mm.).

후처리

  1. additionTo a mixture of 129 g
  2. temperatureThe resulting mixture was heated in a steam bath at 65° C. overnight
  3. extractionextracted with 300 ml
  4. extractionThe ether extract
  5. washwas washed successively with 1N sodium hydroxide, water
  6. dry with materialdried over sodium sulfate
  7. concentrationThe dried ether solution was concentrated
  8. distillationthe oily residue was distilled under reduced pressure
  9. customyielding 152 g

출처 및 근거

ORD 기록
ord-3fb3bb36420a4dc8b445fa8ebd9d94c6
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609735

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