3-(Trifluoromethyl)phenol → 2-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

HRID 64694

반응식

HRID 64694 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[K+].Cl[CH2:15][CH:16]([OH:20])[CH2:17][CH2:18][Cl:19]>O.C(O)(C)C>[Cl:19][CH2:18][CH2:17][CH:16]([OH:20])[CH2:15][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1

참가 물질

6

반응물 3

HCID 73763-(Trifluoromethyl)phenolHCID 14797Potassium HydroxideHCID 170211,4-Dichloro-2-butanol

생성물 1

HCID 131203482-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

시약·촉매·용매 2

HCID 962Water용매2회HCID 3776Isopropanol용매

반응 조건

온도
65 °C

실험 절차

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

후처리

  1. customThe resulting reaction mixture
  2. extractionextracted with 400 ml
  3. extractionThe ether extract
  4. washwas washed with 0.5N sodium hydroxide
  5. dry with materialwith water, dried over sodium sulfate
  6. distillationdistilled under reduced pressure
  7. distillationThe distillate which was collected at 120°-124° C./0.01 mm
  8. customsolidified at room temperature

출처 및 근거

ORD 기록
ord-f451d76dd022479d86c4d6ad57a6b1ae
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609735

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