2-Methyl-6-nitro-1,3-benzoxazol-4-ol → 6-Amino-2-methylbenzo[d]oxazol-4-ol
반응식
[N+:1]([C:4]1[CH:13]=[C:12]([OH:14])[C:7]2[N:8]=[C:9]([CH3:11])[O:10][C:6]=2[CH:5]=1)([O-])=O.[H][H]>C1COCC1.CO.[Pd]>[NH2:1][C:4]1[CH:13]=[C:12]([OH:14])[C:7]2[N:8]=[C:9]([CH3:11])[O:10][C:6]=2[CH:5]=1참가 물질
6
실험 절차
To a solution of 6-nitro-4-hydroxy-2-methylbenzoxazole (5.1 g, 0.026 mole) in THF (100 ml) and methanol (50 ml) were added about 0.5 g of 10 percent palladium on carbon. The mixture was placed on the Parr-shaker apparatus and hydrogenated two hours. At this time hydrogen uptake was complete (6.3 psi, 0.079 mole). The catalyst was removed and the solvents were removed under reduced pressure. The resulting off-white solid (4.1 g, 97.0 percent) was collected and dried. TLC showed the product to be pure. A ninhydrin test for amines was positive. A silver test for hydroxylamine was negative.
후처리
- customwas placed on the Parr-shaker apparatus and hydrogenated two hours
- customThe catalyst was removed
- customthe solvents were removed under reduced pressure
- customThe resulting off-white solid (4.1 g, 97.0 percent) was collected
- customdried
출처 및 근거
- ORD 기록
- ord-e664e72264094f2dbd26e2c171168d8e
- 출처 데이터셋
- uspto-grants-1983_10
- 특허 번호
- US04407930
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