4-Nitro-1-indanyl acetate → 4-Amino-1-indanyl acetate

HRID 647312

반응식

HRID 647312 반응식
[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([N+:14]([O-])=O)[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pt]=O>[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([NH2:14])[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 131024574-Nitro-1-indanyl acetateHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 131024584-Amino-1-indanyl acetate수율 97.6%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매2회

실험 절차

A solution of 10.0 g (0.045 mole) of 4-nitro-1-indanyl acetate in 200 mL of ethanol was mixed with 0.1 g of platinum oxide in 20 mL of ethanol, and the mixture was contacted with hydrogen in a Parr hydrogenator. Upon complete uptake of hydrogen, the reaction mixture was allowed to stand for 16 hours. The platinum oxide was removed by filtration through diatomaceous earth, and the filter cake was washed with ethanol. The ethanol washings were combined with the filtrate, and the whole was concentrated under reduced pressure to give 8.4 g of 4-amino-1-indanyl acetate as an oil.

후처리

  1. customThe platinum oxide was removed by filtration through diatomaceous earth
  2. washthe filter cake was washed with ethanol
  3. concentrationthe whole was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-32139494f2fc43dd8575a97b4c2939f0
출처 데이터셋
uspto-grants-1983_10
특허 번호
US04408057

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